LUNG CANCER Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma
نویسندگان
چکیده
Jenette Creaney, Deborah Yeoman, Leanne K Naumoff, Michelle Hof, Amanda Segal, Arthur William Musk, Nicholas De Klerk, Nora Horick, Steven J Skates, Bruce W S Robinson . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
منابع مشابه
Soluble mesothelin in effusions: a useful tool for the diagnosis of malignant mesothelioma.
BACKGROUND The diagnosis of malignant mesothelioma is frequently difficult, the most common differential diagnosis being reactive pleural conditions and metastatic adenocarcinoma. Soluble mesothelin levels in serum have recently been shown to be highly specific and moderately sensitive for mesothelioma. As most patients with mesothelioma present with exudative effusions of either the pleura or ...
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A n estimated 150 000 patients develop a pleural effusion each year in the UK. Establishing the aetiology of pleural effusions can be challenging as they can be associated with over 50 systemic or pulmonary disorders. Exudative pleural fluids arise from plasma extravasation and contain proteins and cells from the systemic circulation, as well as those released locally from the pleura. This mili...
متن کاملHyaluronan and N-ERC/Mesothelin as Key Biomarkers in a Specific Two-Step Model to Predict Pleural Malignant Mesothelioma
PURPOSE Diagnosis of malignant mesothelioma is challenging. The first available diagnostic material is often an effusion and biochemical analysis of soluble markers may provide additional diagnostic information. This study aimed to establish a predictive model using biomarkers from pleural effusions, to allow early and accurate diagnosis. PATIENTS AND METHODS Effusions were collected prospect...
متن کاملPleural fluid mesothelin for the differential diagnosis of exudative pleural effusions.
BACKGROUND Malignant mesothelioma (MM) is a highly aggressive tumor that can be difficult to diagnose, resulting in a delayed diagnosis in some cases. Recent studies have reported that determination of soluble mesothelin-related peptides (SMRP) in pleural fluid may be a promising marker for use in the diagnosis of MM. PATIENTS AND METHODS Pleural fluid SMRP concentration was measured in 68 pa...
متن کاملPleural Fluid Mesothelin as an Adjunct to the Diagnosis of Pleural Malignant Mesothelioma
RATIONALE The diagnosis of pleural malignant mesothelioma (MM) by effusion cytology may be difficult and is currently controversial. Effusion mesothelin levels are increased in patients with MM but the clinical role of this test is uncertain. OBJECTIVES To determine the clinical value of measuring mesothelin levels in pleural effusion supernatant to aid diagnosis of MM. METHODS AND MEASUREM...
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